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Emepelle is a breakthrough innovation to rejuvenate, restore and re-balance skin affected by menopause. Emepelle is the first and only cosmeceutical to feature MEP Technology®, clinically proven to effectively and safely reinvigorate the natural functions of skin, targeting the root cause of ageing in skin affected by menopause.


MEP Technology® is the only non-hormonal oestrogen receptor stimulator which safely and effectively helps restore the loss of collagen, hyaluronic acid and thickness in skin affected by menopause without systemic effect.


It is not a hormone and does not contain oestrogen - instead it works only on skin cells to both activate and promote

new oestrogen receptors. By combining MEP technology® with a synergistic blend of advanced cosmeceutical ingredients, Emepelle® helps rejuvenate, restore and re-balance skin affected by menopause.

The Emepelle regime includes Emepelle Serum and Emepelle Night Cream. Using just these two products will rejuvenate, re-balance and restore skin affected by menopause – with no need to layer multiple skincare products.

Before & After

Frequently asked questions

Can I use Emepelle products if I am not in menopause?

Emepelle is intended for individuals with Estrogen Deficient Skin, which may occur leading up to menopause. Emepelle Serum and Night Cream contain other active ingredients such as niacinamide, peptides, antioxidants and retinols that benefit skin of all ages.

How can I tell if I have Estrogen Deficient Skin?

Estrogen Deficient Skin results in noticeable dryness, dullness, thinning, and/or wrinkling of facial skin. It typically becomes apparent leading up to menopause, when estrogen levels in the body begin to decline. If you feel like your moisturizer is no longer working or like your skin has lost its youthful “glow”, you may be experiencing Estrogen Deficient Skin.

Are Emmepelle products suitable for all skin types?

Emepelle Serum and Night Cream are suitable for all skin types. Emepelle Night Cream contains retinol, which may cause mild irritation, so please consult your skincare professional if you have retinol sensitivity. It is always best to consult your skincare professional when making changes to your skincare regimen.

Do Emepelle products contain estrogen?

No, Emepelle products do not contain estrogen. Emepelle products do contain MEP™, the only non-hormonal collagen amplifier that is clinically proven to safely and effectively address Estrogen Deficient Skin.

How do I use Emepelle products?

To maximize the benfits of MEP Technology™, it is recommended to use both Emepelle Serum and Emepelle Night Cream in your skincare regimen. For best results, use Emepelle Serum in the morning followed by Emepelle Night Cream in the evening.

Can I use Emepelle if I have a history of breast cancer or another medical condition that requires me to be cautious towards hormones or hormone therapies?

Emepelle is non-hormonal. MEP Technology has been clinically proven to be safe though it has not been tested on individuals with specific medical conditions.

Will I experience any irritation with Emepelle Serum and/or Emepelle Night Cream?

It is normal to experience mild tingling unaccompanied by irritation with the use of Emepelle Serum and/or Emepelle Night Cream. Emepelle Night Cream contains retinol which may cause mild irritation for some skin types. If irritation or redness develops, discontinue use, at least temporarily.


A double-blind randomized pilot study evaluating the safety and efficacy of topical MEP in the facial appearance improvement of estrogen deficient females. By Zoe Diana Draelos. Journal of Drugs Dermatology. 2018;17(11):1032-1035. Read Full Text.

Evaluation of Efficacy of a Skin Care Regimen Containing Methyl Estradiolpropanoate (MEP) for Treating Estrogen Deficient Skin. By Joel L. Cohen. Journal of Drugs Dermatology. 2019 Dec 1;18(12):1226-1230.

Read Full Text.

Clinical studies & research